Dangerous Med Combos in Older Adults

weekly-pill-box.jpgLook twice at the med list before you prescribe these!

Two distinguished guests join me this month, David Juurlink (@DavidJuurlink) and Bryan Hayes (@PharmERToxyGuy), to discuss medication interactions. There are many medications that we commonly prescribe in the ED that can have potentially deadly side effects when combined with other medications that a patient is already on. It is important to always check the patient’s medication list prior to writing a new script. We present two examples of clinical cases in which commonly used medications could prove dangerous in combination with other medications: cellulitis and a community-acquired pneumonia. We discuss potential side effects from medication interactions (with a little pathophysiology thrown in), and some alternative medications that may be safer.


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  2. Ho JM, Juurlink DN. Considerations when prescribing trimethoprim-sulfamethoxazole. CMAJ. 2011;183(16):1851-1858. http://www.ncbi.nlm.nih.gov/pubmed/21989472
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  5. Juurlink DN. The cardiovascular safety of azithromycin. CMAJ. 2014;186(15):1127-1128. http://www.ncbi.nlm.nih.gov/pubmed/25096666
  6. Wright AJ, Gomes T, Mamdani MM, Horn JR, Juurlink DN. The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers. CMAJ. 2011;183(3):303-307. http://www.ncbi.nlm.nih.gov/pubmed/21242274

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1 Response to Dangerous Med Combos in Older Adults

  1. Pingback: 5 Ways to Geriatricize Your ED |

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